Mark Perloe, M.D.

Board Certified Board Certified

  • Retired
Patient Testimonial
We had a great experience with Dr. Perloe. He is very knowledgeable, honest and has great bedside manner.

Dr. Perloe and his staff have been a Godsend to my family. After struggling for YEARS to have a child Dr. Perloe explained to us our options and really dug into what could be going on.

Dr. Perloe and his team are amazing. He was able to help our dreams come true on the first attempt.

I love love love Dr. Perloe and his staff. They are very welcoming and family oriented.

Dr. Mark Perloe was absolutely AMAZING!!! This man treated us like we we more than just a number or paycheck.

Dr. Perloe is amazing. His great bedside manner and expertise help me to feel at ease.

I really loved Dr. Perloe and his staff. I followed every direction and conceived on the first try which was so rewarding.

Dr. Perloe and his staff are so knowledgeable and always gave the best information. Most importantly, I trust them to my core.

Best doctor to see if you’re trying to start a family! Dr. Perloe gave us hope when we thought there was none.

Biography

Dr. Perloe has retired.

Dr. Perloe earned his medical degree from Pennsylvania State University, Hershey Medical Center, and served his residency in Obstetrics and Gynecology at the University of Wisconsin. Dr. Perloe completed his fellowship in Reproductive Endocrinology and Infertility at the University of Minnesota.

He has extensive experience treating conditions related to infertility including polycystic ovary syndrome, recurrent pregnancy loss, menstrual disorders, fibroids, male factor infertility, endocrine disorders, and other reproductive health problems. His patients have access to the latest in vitro fertilization techniques including fertility preservation, the use of donor eggs, donor sperm, and gestational surrogacy.

Dr. Perloe has served as principal investigator in numerous reproductive health research studies including innovative IVF treatments, ovulation induction, polycystic ovary syndrome, as well as investigational medications for the treatment of male erectile dysfunction. He has served as consultant and a task force member to the Women’s Initiative of the American International Health Association and was active in establishing the first approved endoscopy-training center in the former Soviet Union at the Russian National Institute of Women’s Health.

In 1986, he co-authored Miracle Babies and Other Happy Endings for Couples with Fertility Problems. Dr. Perloe is a frequent speaker at community and professional educational seminars, blogs regularly on Facebook, and has created a YouTube PCOS Awareness Channel.

He has published research in medical journals including Human Reproduction, Fertility and Sterility, Obstetrics & Gynecology, Southern Medical Journal, and the International Journal of Obstetrics and Gynecology.

Dr. Perloe is married, has two children, and serves on the board of a local theatre. He enjoys playing with computers, sailing, traveling, and cooking.

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Education

  • Residency: Obstetrics and Gynecology, University of Wisconsin
  • Fellowship: Reproductive Endocrinology and Infertility, University of Minnesota
  • Atlanta Magazine’s Top Doctors for Infertility (2017-2020)
  • Best Fertility Specialist in Atlanta by Kudzu
  • Voted Top Reproductive Endocrinologist in Georgia by HealthTap
  • 2017 Ricardo Azziz PCOS Challenge Advocacy Leadership Award Recipient
  • Atlanta Society of Obstetrics and Gynecology
  • American Society of Reproductive Medicine
  • Georgia Society of Obstetrics and Gynecology
  • Perloe M.: Diagnostic Urine Culture Apparatus and Method of Using Same, US Patent //4,615,979, 1986.
  • Perloe M. and Christie L.: Miracle Babies and Other Happy Endings for Couples with Fertility Problems. Rawson Associates, August, 1986.
  • Perloe M. and Curet LAB.: The Effect of Internal Monitors on Cesarean Section Morbidity. OB/GYN. 53:35f, 1979.
  • Perloe M. et al.: Laparoscopic Tubal Banding. Video tape for resident education, 1978.
  • Perloe M. et al.: Endometrial Cancer. Video tape for resident education, 1979.
  • Perloe M. and Speed J.: Screening for Asymptomatic Bacteriuria in Pregnancy. Presented at the Gynecologic Urology Society, New Orleans, November 19, 1981.
  • Perloe M.: Infertility, Klinefelter’s Syndrome. Microsoft Encarta 98
  • Perloe M, Adhesion Study Group: Permanent Implantation of Expanded Polytetraflouroethylene Is Safe in Pelvic Surgery, submitted to Human Reproduction.
  • Hurst B.S., Perloe M., et al: Permanent implantation of expanded polytetrafluoroethylene is safe for pelvic surgery. Human Reproduction 14:925, 1999.
  • Perloe M, Sills ES,: Metformin treatment of clomiphene resistant polycystic ovary syndrome. Allahbadia G (ed): in Manual of Ovulation Induction October 99, Rotunda Press London-Bombay
  • Sills ES, Perloe M, Palermo GD: Correction of hyperinsulinemia in subfertile women with clomiphene-resistant polycystic ovary syndrome: a review of therapeutic rationale and reproductive outcomes. Eur J Obstet Gynecol Biol Reprod 92/2:148, 2000 1999.
  • Sills ES, Perloe M, et al: Preliminary Experience with Metformin Treatment of Polycystic Ovary Syndrome: Reproductive Outcome Among 20 Consecutives Patients, presented ASRM-CFAS, Sept 99, Toronto, CA
  • Scieneaux TL, Sills ES, Perloe M, Daly JP, Schattman GL: Transvaginal ultrasonographic identification of appendicitis in the setting of chronic pelvic pain and endometriosis. South Med J. 93:73, 2000.
  • Sills ES, Perloe M, Levy DP, Genton MG, Schattman GL, Tucker MJ: patient perception and awareness regarding diagnosis and treatment of polycystic ovary syndome (PCOS) as measured by confidential self-reports. 56th Annual Meeting, American Society for Reproductive Medicine, San Diego (October 2000).
  • Perloe M, Wittkowski KM, Sills ES, Tucker MJ, Palermo GD: Separation of motile human spermatozoa in assisted reproduction: evaluation of centrifugation and non-centrifugation based techniques. 48th Annual Meeting, Pacifac Coast Reproductive Society, Rancho Mirage [Calif.] (April 2000).
  • Perloe M, Levy DP, Sills ES.: Strategies for ascertaining ovarian reserve among women suspected of subfertility. Int J Fertil Womens Med. 2000 May-Jun;45(3):215-24. Review.
  • Sills ES, Perloe M, Palermo GD.: Correction of hyperinsulinemia in oligoovulatory women with clomiphene-resistant polycystic ovary syndrome: a review of therapeutic rationale and reproductive outcomes. Eur J Obstet Gynecol Reprod Biol. 2000 Aug;91(2):135-41. Review.
  • Perloe M, Levy DP, Sills ES: Strategies for ascertaining ovarian reserve among women suspected of subfertility. Int J Fertil Womens Med. 45:215, 2000.
  • Perloe M: On Becoming a Netizen. Atlanta Medicine 74, 2000.
  • Perloe M: editor, Internet Medicine Issue. Atlanta Medicine 74, 2000.
  • Sills ES, Genton MG, Perloe M, Schattman GL, Bralley JA, Tucker MJ: Plasma homocysteine, fasting insulin, and androgen patterns among women with polycystic ovary syndrome and infertility. J Obstet Gynaecol Res 27, 2001.
  • Sills ES, Drews CD, Perloe M, Kaplan CE, Tucker MJ: Periovulatory serum human chorionic gonadotropin (hCG) concentrations following subcutaneous and intramuscular non-recombinant hCG use furing ovulation induction: a prospective, randomized comparison. Fertil Steril 75, 2001.
  • Sills ES, Perloe M, Tucker MJ, Kaplan CR, Palermo GD: Successful ovulation induction, coneption, and normal delivery after chronic therapy with etanercept: a novel recombinant fusion anti-cytokine treatment for rheumatoid arthritis. Am J Reprodu Immunol 2001.
  • Elliott JL, Hosford SL, Demopoulos RI, Perloe M, Sills ES: Endometrial adencarcinoma and polycystic ovary syndrome: risk factors, management and prognosis. South Med J 94:529, 2001.
  • Sills ES, Perloe, M, Tucker MJ, Kaplan CR, Genton, MG, Schattman GL: Diagnostic and treatment characteristics of polycystic ovary syndrome: descriptive measurements of patient perception and awareness from 657 confidential self-reports. BMC Women’s Health 1:3 2001.
  • Scineaux TL, Sills ES, Perloe M, Daly JP, Schattman GL.: Transvaginal ultrasonographic identification of appendicitis in a setting of chronic pelvic pain and endometriosis. South Med J. 2001 Jan;94(1):73-4.
  • Sills ES, Perloe M, Kaplan CR, Sweitzer CL, Morton PC, Tucker MJ: Uncomplicated pregnancy and normal singleton delivery after surgical excision of heterotopic (corneal) pregnancy following in vitro fertilization/embryo transfer. Arch GYN OB Abstract Vol 266, 181, 2002.
  • Sills ES, Perloe M, Levy DP, Palermo GD. [Adnexal defect identified with hysterosalpingogram and laparoscopy during infertility evaluation] J Gynecol Obstet Biol Reprod (Paris). 2002 Dec;31(8):772-4. French
  • Sills ES, Wittkowski KM, Tucker MJ, Perloe M, Kaplan CR, Palermo GD. Comparison of centrifugation- and noncentrifugation-based techniques for recovery of motile human sperm in assisted reproduction. Arch Androl. 2002 Mar-Apr;48(2):141-5.
  • Sills ES, Sholes TE, Perloe M, Kaplan CR, Davis JG, Tucker MJ. Characterization of a novel receptor mutation A–>T at exon 4 in complete androgen insensitivity syndrome and a carrier sibling via bidirectional polymorphism sequence analysis. Int J Mol Med. 2002 Jan;9(1):45-8.
  • Sills ES, Perloe M, Kaplan CR, Sweitzer CL, Morton PC, Tucker MJ.: Uncomplicated pregnancy and normal singleton delivery after surgical excision of heterotopic (cornual) pregnancy following in vitro fertilization/embryo transfer. Arch Gynecol Obstet. 2002 Jul;266(3):181-4. Review.
  • Sills ES, Sweitzer CL, Morton PC, Perloe M, Kaplan CR, Tucker MJ.: Dizygotic twin delivery following in vitro fertilization and transfer of thawed blastocysts cryopreserved at day 6 and 7. Fertil Steril. 2003 Feb;79(2):424-7.
  • Sills ES, Kaplan CR, Perloe M, Tucker MJ. Laparoscopic approach to an uncommon adnexal neoplasm associated with infertility: serous cystadenofibroma of the fallopian tube. J Am Assoc Gynecol Laparosc. 2003 Nov;10(4):545-7.
  • Wehbe SA, Ghulmiyyah LM, Carroll KT, Perloe M, Schwartzberg DG, Sills ES. Correlations from gadopentetate dimeglumine-enhanced magnetic resonance imaging after methotrexate chemotherapy for hemorrhagic placenta increta. Biomagn Res Technol. 2003 Nov 14;1(1):3.
  • Ghulmiyyah LM, Perloe M, Tucker MJ, Zimmermann JH, Eller DP, Sills ES. Monochorionic-triamniotic triplet pregnancy after intracytoplasmic sperm injection, assisted hatching, and two-embryo transfer: first reported case following IVF. BMC Pregnancy Childbirth. 2003 Aug 8;3(1):4.
  • Sills ES, Drews CD, Perloe M, Tucker MJ, Kaplan CR, Palermo GD. Absence of profound hyperinsulinism in polycystic ovary syndrome is associated with subtle elevations in the plasminogen activator inhibitor system. Gynecol Endocrinol. 2003 Jun;17(3):231-7.
  • Sills ES, Perloe M, Kaplan CR, Schlegel PN, Palermo GD. Bilateral orchiectomy for the surgical treatment of complete androgen insensitivity syndrome: patient outcome after 1 year of follow-up. J Laparoendosc Adv Surg Tech A. 2003 Jun;13(3):193-7.
  • Sills ES, Sweitzer CL, Morton PC, Perloe M, Kaplan CR, Tucker MJ. Dizygotic twin delivery following in vitro fertilization and transfer of thawed blastocysts cryopreserved at day 6 and 7. Fertil Steril. 2003 Feb;79(2):424-7.
  • Sills ES, Conway SC, Kaplan CR, Perloe M, Tucker MJ. First successful case of in vitro fertilization-embryo transfer with venom immunotherapy for hymenoptera sting allergy. Clin Mol Allergy. 2004 Oct 19;2(1):11.
  • Sills ES, Ghulmiyyah LM, Wehbe SA, Atkinson PF, Perloe M, Tucker MJ. Microstructural observations of villous and membrane histology in monochorionic triplet placenta after in vitro fertilization. Histol Histopathol. 2004 Oct;19(4):1241-4.
  • Sills ES, Perloe M, Stamm LJ, Kaplan CR, Tucker MJ. Medical and psychological management of recurrent abortion, history of postneonatal death, ectopic pregnancy and infertility: successful implementation of IVF for multifactorial reproductive dysfunction. A case report. Clin Exp Obstet Gynecol. 2004;31(2):143-6.
  • Sills ES, Fryman JT, Perloe M, Michels KB, Tucker MJ. Chromatin fluorescence characteristics and standard semen analysis parameters: correlations observed in andrology testing among 136 males referred for infertility evaluation. J Obstet Gynaecol. 2004 Jan;24(1):74-7.
  • Cousineau TM, Green TC, Corsini E, Seibring A, Showstack MT, Applegarth L, Davidson M, Perloe M.: Online psychoeducational support for infertile women: a randomized controlled trial. Hum Reprod. 2008 Mar;23(3):554-66. Epub 2007 Dec 18.
  • Cousineau TM, Green TC, Corsini E, Seibring A, Showstack MT, Applegarth L, Davidson M, Perloe M. Online psychoeducational support for infertile women: a randomized controlled trial. Hum Reprod. 2008 Mar;23(3):554-66. Epub 2007 Dec 18.
  • Worrilow KC, Eid S, Woodhouse D, Perloe M, Smith S, Witmyer J, Ivani K, Khoury C, Ball GD, Elliot T, Lieberman J.: Use of hyaluronan in the selection of sperm for intracytoplasmic sperm injection (ICSI): significant improvement in clinical outcomes–multicenter, double-blinded and randomized controlled trial. Hum Reprod. 2012 Nov 30. [Epub ahead of print]
  • Worrilow KC, Eid S, Woodhouse D, Perloe M, Smith S, Witmyer J, Ivani K, Khoury C, Ball GD, Elliot T, Lieberman J. Use of hyaluronan in the selection of sperm for intracytoplasmic sperm injection (ICSI): significant improvement in clinical outcomes–multicenter, double-blinded and randomized controlled trial. Hum Reprod. 2013 Feb;28(2):306-14.Epub 2012 Nov 30.
  • Ravichandran K, McCaffrey C, Grifo J, Morales A, Perloe M, Munne S, Wells D, Fragouli E.Mitochondrial DNA quantification as a tool for embryo viability assessment: retrospective analysis of data from single euploid blastocyst transfers. Hum Reprod. 2017 Jun 1;32(6):1282-1292.
  • Wells D, Ravichandran K, McCaffrey C, Grifo J, Morales A, Perloe M, Munne S, Fragouli E. Reply: Mitochondrial DNA Quantification-the devil in the detail. Hum Reprod. 2017 Oct 1;32(10):2150-2151.

Q&A

Advances in reproductive technology have allowed us to work closely with people wishing to build a family. Exploring these new family building options and helping couples make these decisions is the best part of my job.

My own children. They are intelligent, kind, and creative. It is truly a pleasure watching them become people who make me proud.

Kayaking, theatre, dog training.

I started pilot training at age 11. I started NASA scientist training while in high school.

SGF is a group of people dedicated to family building by offering the best technology in a truly focused, patient-centered environment.

Pet Therapy certification with my dog, Andrew. I can’t wait to share his love for people to help them feel at ease in challenging situations.

The best approach is to be certain patients understand the various options that might be open to them and empowering them to be active participants in the decision-making process.

I’m a helluva nice, caring guy.

Every day and every patient has a unique story to share. I enjoy hearing each of them.

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Singles Family Building Support Group (MD, VA, D.C., FL and TX patients)
January 4, 2025

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Emotional Support

Singles Family Building Support Group (MD, VA, D.C., FL and TX patients)
January 6, 2025

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2024 Shady Grove Fertility

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